Year: 2014 | Month: March and June | Volume 2 | Issue 1 and 2
Insilico Structural Annotation of Human Cyclin-Dependent Kinase
DOI:Coming soon...
Abstract:
CDK2 is a member of the cyclin-dependent protein kinase family that is ubiquitously expressed. its catalytic subunit of the cyclin-dependent protein kinase complex, whose activity is restricted to the G1-S phase, and essential for cell cycle G1/S phase transition. It is associated with and is regulated by the regulatory subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A) and p27Kip1 (CDKN1B). it phosphorylates multiple cellular substrates including SMAD3 and FOXO1. Phosphorylation of FOXO1 leads to its inhibition.
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